Bone Abstracts

Objectives: Bone remodeling and maintenance require a fine balance between bone formation of osteoblasts and resorption of osteoclasts. Therefore, various skeletal disorders cause by imbalanced differentiation and activities of these cells. Receptor activator of NF-κB ligand (RANKL) induces Ca2+ oscillations and activates nuclear factor of activated T cells 1 (NFATc1) during osteoclast differentiation. Although Ca2+ oscillations play a key role for o...

Bone remodeling and maintenance require a fine balance between bone formation of osteoblasts and resorption of osteoclasts. Therefore, various skeletal disorders cause by imbalanced differentiation and activities of these cells. RANKL (receptor activator of NF-kB ligand) induces Ca2+ oscillations and activates NFATc1 (nuclear factor of activated T cells i) during osteoclast differentiation. Although Ca2+ oscillations play a key role for osteoclastogenesis...

Ca2+ signaling and NFATc1 activation are essential for RANKL-induced osteoclast differentiation through the induction of Ca2+ oscillation, calcineurin activation, and translocation of NFATc1 into the nucleus. Homer proteins are scaffold proteins that have been proposed to modulate multiple Ca2+ signaling proteins, including inositol 1,4,5-triphosphate receptors, ryanodine receptors, transient receptor potential channels. In this study, we inves...